Yesterday I started trying to use it again with a Nokia N73, and to my displeasure the Tiger version is actually less useful, and more confusing, than the previous version. There's a menu bar option that will, ostensibly, make syncing really easy--but in the 2.0 version of iSync, it only syncs with .Mac (not your other devices, like phones), unless you have iSync open already. So the menu option "Sync Now" does something completely different depending on whether you have iSync open or not.
Not only that, but if you do open iSync, there's a "Sync Devices" button that does something else--it only syncs to your devices, and not to .Mac:
I feel bad for the poor documentation writer who had to make this seem logical and intentional as opposed to a bizarre implementation choice.If you have .Mac, mobile devices, an iPod, and a PalmOS device and want to sync them at the same time, here's how: Open iSync version 2.0, then choose Sync Now from the Sync Status menu (not the Sync Devices button). When prompted, press the HotSync button on your PalmOS device's cradle.